Expedition 72 was the 72nd long-duration expedition to the International Space Station (ISS). The expedition began with the departure of Soyuz MS-25 on 23 September 2024 with NASA astronaut Sunita Williams taking over the ISS command. It continues the extensive scientific research conducted aboard the ISS, focusing on biology, human physiology, physics, and materials science. The crew members also maintain and upgrade the space station systems.