Karen Sue Pence is an American schoolteacher who was the second lady of the United States from 2017 to 2021. She is married to the 48th vice president of the United States, Mike Pence. Pence was also the first lady of Indiana from 2013 to 2017 during her husband’s tenure as the 50th governor of that state. In 2023, she released a book detailing her life as a political spouse, titled When It's Your Turn to Serve: Experiencing God's Grace in His Calling for Your Life.