Las Cruces is the second-most populous city in the U.S. state of New Mexico and the seat of Doña Ana County. As of the 2020 census, its population was 111,385, making Las Cruces the most populous city in both Doña Ana County and southern New Mexico. The Las Cruces metropolitan area had an estimated population of 213,849 in 2017. It is the principal city of a metropolitan statistical area which encompasses all of Doña Ana County and is part of the larger El Paso–Las Cruces combined statistical area with a population of 1,088,420, making it the 56th-largest combined statistical area in the United States.