Beetlejuice Beetlejuice is an upcoming American fantasy comedy horror film directed by Tim Burton from a screenplay by the writing team of Alfred Gough and Miles Millar, based on a story by Gough, Millar, and Seth Grahame-Smith. A sequel to Beetlejuice (1988) and the second film of the Beetlejuice franchise, it stars Michael Keaton, Winona Ryder, and Catherine O'Hara reprising their roles alongside new cast members Justin Theroux, Monica Bellucci, Jenna Ortega, and Willem Dafoe.