San Bernardino is a city in and the county seat of San Bernardino County, California, United States. Located in the Inland Empire region of Southern California, the city had a population of 222,101 in the 2020 census, making it the 18th-most populous city in California. The Riverside–San Bernadino metropolitan area at 4.74 million residents is the 12th-largest metropolitan area in the nation. San Bernardino is the economic, cultural, and political hub of the San Bernardino Valley and Inland Empire.